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Zolpidem tartrate, commonly known by the brand name Ambien, has made its mark as an effective remedy for treating various sleep disorders. It was initially approved for use in the late 1980s and quickly gained recognition for being safe and effective.
People who buy zolpidem tartrate today get a reliable solution with a history of success. Marketed as a so-called 'Z-drug', this treatment is considered safer than its benzodiazepine analogues while offering the same benefits. This page will cover the basic rules of using the treatment safely.
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A common sleep disorder, insomnia is defined by persistent problems with sleep initiation and remaining asleep throughout the night. The consequences of that are daytime tiredness and irritation. Sleep scientists categorize insomnia into two types, acute and chronic.
Acute insomnia is typically short-term and often linked to specific triggers, such as stress, pain, or other things that might cause a disturbance in sleep patterns. It generally lasts from one night to a few weeks. Chronic sleeplessness is more severe and persistent, lasting for months or even years. Both can be helped with zolpidem tartrate.
Insomnia is a widespread condition in the UK. Based on the results of a recent Sleep Council survey, some 30% of UK adults said they had symptoms regularly. Over 10% of respondents reported suffering from chronic insomnia, with persistent sleep issues lasting for three months or more.
Access to safe treatments like 'Z-drugs' can help many people improve their lives. New users should consult with a GP before starting and follow dosage instructions carefully.
When faced with a sleep disorder, the UK customer today has seemingly unlimited options. There are natural remedies, melatonin and magnesium additives, not to mention the many sorts of talk therapy. Not all of these means are equally effective.
When it comes to stronger sleep aids, the choice is usually between benzodiazepines and 'Z-drugs'. Zolpidem tartrate, as mentioned, is one of the better drugs on the UK market, offering reliable results with relatively low risk. One of the most notable advantages of its class is that it is less likely to cause dependence than benzodiazepines.
Zolpidem tartrate is appreciated for reliability. With a quick onset time of about 30 minutes to an hour, the user goes to sleep fast and rests through the night, uninterrupted. It has a relatively short half-life, which means it leaves the body fast after being metabolised.
There is no drowsiness the next morning, people wake up feeling energetic, ready to take on the day. The benefits of treating insomnia are immense, as it can improve mental and physical health, letting people socialise more and perform better at work.
Every prospective user should have a thorough consultation with a GP before starting any prescription treatment. In case there are contraindications or the user is prone to adverse effects, the consulting physician can recommend an alternative.
The mechanism of action of this medication is based on modifying the potency of a neuromediator called ϒ-aminobutyric acid, or GABA. Normally, GABA inhibits brain function when the nervous system needs to relax. When people are finding it difficult to relax because of anxiety or stress, the effect of GABA can be boosted to help.
This is exactly what zolpidem tartrate does. It binds to receptors in the brain and makes them more sensitive, amplifying the effect of GABA. This results in a sedation of the central nervous system which reduces the excitability of brain neurons.
As a result, zolpidem tartrate produces a sedative effect, making it easier for people with insomnia to fall and to stay asleep. This mechanism is similar to the way benzodiazepines work in the brain, but 'Z-drugs' were synthesized as a safer alternative, so there are slight differences in how they produce their effect. For the user, it means there is a lower potential for dependency than with benzodiazepines.
The precise and well-studied mechanism of action and a short, easily controllable duration, make the treatment an effective choice for those struggling with sleep onset or maintenance issues. It is normally prescribed for no more than 4 weeks. This minimises exposure to withdrawal and dependency.
There are a few side effects to taking sleep aids that can be avoided by following instructions. It is normally prescribed for short-term relief from acute insomnia. The recommended dosage of zolpidem tartrate should be determined by a GP in each individual case.
Zolpidem tartrate comes in 5 mg and 10 mg strengths. According to general NHS guidelines, the usual dose for sleep is one 10 mg pill. Older patients (65 years and over) or those with kidney and liver conditions should start with a 5 mg pill. Take the tablets just before bedtime, and allocate 7-8 hours for sleep to avoid daytime drowsiness.
Make sure not to mix this drug with alcohol, as this will likely amplify its effects and may cause impaired movement coordination. Stimulants like coffee or sugary drinks, on the other hand, might negate the effects of zolpidem tartrate. In some cases, it will be prescribed 2 or 3 times a week instead of every night.
The zolpidem tartrate dosage cannot be changed abruptly and the treatment cannot be stopped suddenly. When stopping, the patient should taper off under medical supervision, to prevent withdrawals.
If you experience severe adverse reactions or if you have any concerns, consult a medical professional for advice. Following usage and dosage instructions ensures that therapy with zolpidem tartrate is effective and safe.
Just like other medications, zolpidem tartrate may lead to some side effects, although they are unlikely with correct use. Common ones are vertigo and lethargy. There have been some reports of patients experiencing vivid dreams, dyspepsia as well as headaches.
Changes in appetite are not common but possible when taking this drug. It's worth noting that these may occasionally lead to weight fluctuations. These adverse reactions are mild in nature and, in general, don't last very long. If they do, they should be reported to the consulting physician.
Although they are rare, more serious side effects are possible with zolpidem tartrate. Sleepwalking is an obvious example, but sleep-eating or even memory lapses may also occur. If anything like that happens to the user, or they experience other serious side effects (a fuller list can be found at the NHS website), seeking medical guidance is advisable.
Zolpidem tartrate may not be suitable for everyone. It should not be taken by people with a history of allergic reaction to 'Z-drugs'. People who have a history of alcohol or substance abuse should use zolpidem tartrate with extreme caution, as it carries a risk of dependency. Pregnant or breastfeeding women should consult their healthcare provider before using this treatment, it is generally not recommended.
Zolpidem tartrate is mostly used to treat insomnia but it can also help with anxiety symptoms. The conditions often go hand in hand, anxiety causes insomnia and not getting enough sleep leads to more anxiety the next day. Zolpidem tartrate can break that cycle.
The GABA-enhancing mechanism of action, described above, slows down brain activity. With a zolpidem tartrate dosage that is considered normal, this causes sedation. A lower dosage is usually given for anxiety than for insomnia so as to avoid putting the user to sleep. Zolpidem tartrate is sometimes used in conjunction with other forms of therapy when treating excessive anxiousness.
Doctors might start a patient off at 5 mg of zolpidem tartrate, this is half of the prescribed dosage for insomnia in healthy adults. A smaller dosage will be enough to combat anxiety without causing sedation or over tiredness.
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Last Reviewed: 24th September 2024
Next Review Due: October 2025
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